There’s something magical about the combination of creamy macaroni and cheese and hearty meatloaf, especially when they come together in a dish called Mac and Cheese Meatloaf Casserole. Picture it: a bubbling, cheesy dream with a golden crust, inviting you to dig in. Crockpot Taco Casserole It’s comfort food at its finest, oozing with flavors that hug your taste buds like an old friend you haven’t seen in years. For more inspiration, check out this Cozy Autumn Wild Rice Soup recipe.
Now, imagine serving this delicious concoction at your next family gathering. The aroma wafts through the house, turning heads and igniting conversations. Each bite is a delightful surprise—cheesy goodness meets savory meatloaf—a match made in culinary heaven! Trust me; this dish will be the star of your dinner table.
[info_box title=”Why You’ll Love This Recipe”] This Mac and Cheese Meatloaf Casserole is easy to prepare and requires minimal cleanup. The flavor explosion will have everyone asking for seconds. It’s visually appealing with its golden top and cheesy layers. Versatile enough to serve on any occasion, it works well for family dinners or potlucks. [/info_box]
I remember the first time I made this casserole for my friends. Their faces lit up as they took their first bites—it was pure joy!

Essential Ingredients
Here’s what you’ll need to make this delicious dish:
Ground Beef: Use lean ground beef for a balanced flavor without excess grease.
Elbow Macaroni: Cook al dente so it holds up during baking but remains tender.
Shredded Cheddar Cheese: A must-have for that gooey, melty texture; go for sharp cheddar for more flavor.
Breadcrumbs: Use seasoned breadcrumbs to add crunch to the top layer of your casserole.
Eggs: Acts as a binder to hold everything together; don’t skip this step!
Milk: Adds creaminess to the cheese sauce; use whole milk for best results.
Ketchup: A classic topping that adds a hint of sweetness; feel free to mix it with BBQ sauce for an extra kick.
Onion and Garlic Powder: Essential seasonings that elevate the overall flavor profile.
Salt and Pepper: Use these basic seasonings to taste; adjust according to your preference.
The full ingredients list, including measurements, is provided in the recipe card directly below.
Let’s Make it Together
Preheat Your Oven: Preheat your oven to 350°F (175°C). Grease a 9×13 inch baking dish with cooking spray or butter—nobody wants sticking drama during dinner!
Boil That Pasta!: Bring a large pot of salted water to a boil. Add elbow macaroni and cook until al dente according to package directions. Philly Cheesesteak Pasta Drain and set aside while you work on other layers.
Mix the Meatloaf Base: In a large bowl, combine ground beef, eggs, breadcrumbs, onion powder, garlic powder, salt, and pepper. Mix until just combined—don’t overdo it; nobody wants tough meatloaf!
Create the Cheesy Sauce: In another bowl, mix shredded cheddar cheese with milk until creamy. This will be your gooey goodness layer—just imagine that melty sensation when it all comes together.
Layer It Up!: In your greased baking dish, spread half the meat mixture as the base layer. Top with half of the macaroni followed by half of the cheesy sauce. Repeat until everything is layered beautifully.
Add Toppings & Bake!: Spread ketchup evenly over the top layer or mix in BBQ sauce for flavor flair. Bake uncovered for about 45-50 minutes or until bubbly and golden brown on top—you want that picture-perfect crust!
Enjoy every cheesy bite of this unforgettable Mac and Cheese Meatloaf Casserole! Cottage Cheese Brownie Bites.
[info_box title=”You Must Know”] Mac and Cheese Meatloaf Casserole combines comfort food with creativity, making it a family favorite. The cheesy goodness and meaty texture create a delightful dish that is both satisfying and easy to prepare. Perfect for busy weeknights or cozy gatherings, it’s a hit every time. [/info_box]
Perfecting the Cooking Process
Start by preheating your oven to 350°F (175°C). Cook the macaroni until al dente. While the pasta cooks, mix ground meat with spices and form into a loaf. Combine cheese sauce and macaroni, then layer in your baking dish.

Add Your Touch
Feel free to swap out the ground beef for turkey or chicken for a lighter twist. Add veggies like spinach or bell peppers for extra nutrition and flavor. Honey Pepper Chicken Mac and Cheese You can also experiment with different types of cheese for a unique taste.
Storing & Reheating
Store leftovers in an airtight container in the fridge for up to three days. To reheat, place in an oven at 350°F (175°C) until warmed through, about 20 minutes. You can also microwave individual portions, but they may lose some creaminess.
[info_box title=”Chef’s Helpful Tips”] For optimal flavor, season the meat well to enhance the dish’s overall taste. Always let the casserole rest before serving to improve texture and make slicing easier. Experiment with different cheese blends to discover new favorite combinations! [/info_box]
Cooking this casserole reminds me of family gatherings where everyone would gather around the table, eagerly awaiting that first cheesy bite; those moments are simply unforgettable.

FAQ
Can I use gluten-free pasta for this casserole?
Yes, gluten-free pasta works great; just adjust cooking time as needed.
How do I make this dish spicier?
Add jalapeños or spicy cheese to kick up the heat level in your casserole.
Can I prepare this ahead of time?
Absolutely! Assemble it beforehand and refrigerate; bake when ready to serve.

Mac and Cheese Meatloaf Casserole
- Total Time: 1 hour 10 minutes
- Yield: Serves 8
Description
Mac and Cheese Meatloaf Casserole is the ultimate comfort food fusion, combining creamy macaroni and cheese with hearty meatloaf for a dish that’s both satisfying and delicious. This bubbling casserole features layers of cheesy goodness and savory meat, topped with a golden crust that will have your family coming back for seconds. Perfect for family gatherings or cozy dinners, it’s a crowd-pleaser that brings warmth to any table.
Ingredients
- 1 lb lean ground beef
- 2 cups elbow macaroni
- 2 cups shredded sharp cheddar cheese
- 1 cup seasoned breadcrumbs
- 2 large eggs
- 1 cup whole milk
- 1/2 cup ketchup (or BBQ sauce)
- 1 tsp onion powder
- 1 tsp garlic powder
- Salt and pepper to taste
Instructions
- Preheat oven to 350°F (175°C) and grease a 9×13 inch baking dish.
- Boil salted water; add elbow macaroni and cook until al dente. Drain and set aside.
- In a bowl, mix ground beef, eggs, breadcrumbs, onion powder, garlic powder, salt, and pepper until combined.
- In another bowl, blend cheddar cheese with milk until creamy.
- Layer half the meat mixture in the baking dish, followed by half the macaroni and cheese sauce. Repeat layers.
- Spread ketchup or BBQ sauce on top and bake uncovered for 45-50 minutes or until bubbly and golden brown.
- Prep Time: 20 minutes
- Cook Time: 50 minutes
- Category: Main
- Method: Baking
- Cuisine: American
Nutrition
- Serving Size: 1 slice (about 200g)
- Calories: 410
- Sugar: 6g
- Sodium: 780mg
- Fat: 22g
- Saturated Fat: 10g
- Unsaturated Fat: 11g
- Trans Fat: 0g
- Carbohydrates: 30g
- Fiber: 2g
- Protein: 24g
- Cholesterol: 85mg






